For clinical purposes, must include all of the following:
- An infant who is <5 months of age when the symptoms start and stop
- Recurrent and prolonged periods of infant crying, fussing, or irritability reported by caregivers that occur without obvious cause and cannot be prevented or resolved by caregivers
- No evidence of infant failure to thrive, fever, or illness
For clinical research purposes, a diagnosis of infant colic must meet the preceding diagnostic criteria and also include both of the following:
- Caregiver reports infant has cried or fussed for 3 or more hours per day during 3 or more days in 7 days in a telephone or face-to-face screening interview with a researcher or clinician
- Total 24-hour crying plus fussing in the selected group of infants is confirmed to be 3 hours or more when measured by at least one prospectively kept, 24-hour behaviour diary