KetoConference2024 - Predictors of ketogenic diet efficacy in paediatric epilepsy management: literature review

In this presentation, Christian Feghali reviews the clinical factors influencing the efficacy of the ketogenic diet (KD) in managing paediatric epilepsy. This session evaluates current research, highlighting key predictors of success in children with pharmacoresistant epilepsies who undergo KD therapy.

Key topics include:

• Effectiveness of KD: An analysis of how KD can lead to significant seizure reduction in paediatric patients.
• Predictive factors: The role of early response, electroencephalogram findings, imaging patterns, and serum beta-hydroxybutyrate levels in predicting longer-term seizure control.
• Patient selection: Identifying patient cohorts most likely to respond positively to KD, including those with non-focal seizures and genetic aetiologies.
• Areas for further research: Limitations and gaps in the current studies, such as the influence of age and seizure onset, and recommendations for future research.

This literature review offers valuable insights for clinicians on selecting the right candidates for ketogenic diet therapy and developing individualised management plans for paediatric epilepsy patients.